If I recall correctly, when I ran the half marathon in 2008, I made the mistake of going out too fast and trying to maintain that momentum by attacking the climb up Western Avenue to West 25th Street.
This steep stretch is roughly a half mile long, but the climb actually starts on Paseo del Mar and continues for an entire mile with an elevation increase of 250 feet.
I still have a tendency to start races too fast, but who knows what I'll do next week...since technically this will not be a race.